Zestica Moisture^™ User Trial

Introduction

59 women were recruited (54 completed) into a 14-day in-home, user trial of Zestica Moisture^™, with daily application of the vaginal lubricant for the first five days of this 2-week period. All women were 50 years or over, were either menopausal or post-menopausal, and had conditions related to vaginal dryness.

A majority (83%) of the women complained of vaginal dryness, with other baseline vaginal symptoms being reported as discomfort (46% of women), painful intercourse (42%), irritation (36%), and vaginal atrophy (31%) [Figure 1].

Figure 1. Baseline Symptoms

Most of women were sexually active with 59% having intercourse at least twice a month and a further 28% having intercourse less frequently.

Speed of onset of relief after using Zestica Moisture

Onset of relief from symptoms was rapid: 56% of women felt the product provided almost immediate relief (in less than 1 minute), and in 98% it caused their symptoms to disappear within 1 hour.

Duration of relief.

After 1 Application The duration of relief after a single application was variable with some women finding that symptoms returned within 4 hours, whilst a quarter of them had complete relief until the lubricant was next applied 24 hours later [Figure 2]. In total, 57% of users had at least 12 hours of symptom relief after just one application of Zestica Moisture.

Figure 2. Duration of Symptom Relief after Single Application of Zestica Moisture

After 5 Daily Applications

At Day 7 (i.e. 2 days after the fifth and last daily application), 81% of users were still symptom-free. Symptom relief continued to Day 9 for just under half (48%) of women, and even at Day 14 (9 days after last dose), 42% of women remained symptom-free.

Symptom Relief

In keeping with these positive results, 94% of users felt that the lubricant was effective at relieving dryness, (none felt it was not effective at all), and similarly 94% found that the product was effective at relieving vaginal discomfort (again none found that the product was ineffective) [Figure 3]. 70-80% of women found that both symptoms were relieved either `very' or `highly' effectively. The product was similarly effective at relieving irritation and painful intercourse, with 87% of women finding relief from irritation and 83% relief from painful intercourse. There were two and one women respectively in these two groups who found the product ineffective.

Further Observations

Over half of the women (56%) were more comfortable having intercourse, with 20% reporting feeling more confident about sexual intercourse, and 17% saying it improved their sexual experience. Again over half of the group (52%) reported feeling more comfortable throughout the day.

Overall, 89% of women taking part in the study would be interested in buying the product.

There were no reports of irritation caused by the product.